Volume-1 ,Issue-5, December-2025

The combination of plant-derived bioactives and nanotechnology, known as "nano-phytomedicine," has shown promise in overcoming the intrinsic drawbacks of traditional phytochemicals, such as their poor solubility, low bioavailability, and restricted tissue targeting. Recent developments in nanocarrier systems, including as polymeric nanoparticles, lipid-based carriers, nanoemulsions, SNEDDS, and green-synthesized nanoparticles, are highlighted in this systematic review along with how they can improve pharmacokinetics, efficacy, and safety. Improved results in preclinical and early clinical investigations are presented for disease-oriented applications in cancer, neurological, metabolic, and infectious illnesses. Along with new possibilities in AI-guided nanoformulation design, individualized phytomedicine, and interaction with conventional medical systems, the main obstacles in toxicity, regulatory approval, clinical translation, and standardization are examined. All things considered, nano-phytomedicine presents a revolutionary strategy by fusing cutting-edge nanotechnology with conventional therapies to provide safe, focused, and patient-centered treatments.

Keyword: Nano-phytomedicine; phytochemical delivery systems,Bioavailability, Bioactivity, Nanotechnology, Phytomedicine.