Volume-1 ,Issue-5, December-2025

The clinical effectiveness of therapeutic medicines is largely dependent on oral bioavailability; however, many medications encounter difficulties because of poor solubility, limited permeability, instability, and first-pass metabolism. Prodrug design, molecular modification, lipid-based systems, polymeric and nanocarrier formulations, vesicular carriers, inclusion complexes, and solid-state engineering are some of the methods to get around these restrictions that are examined in this paper. Advanced methods for enhancing absorption, stability, and therapeutic results are also covered, including nanotechnology-based platforms, biopharmaceutical tactics, and intelligent targeted delivery systems. Alongside commercial goods and case studies that show clinical translation, evaluation techniques such as in vitro dissolution, permeability investigations, in vivo pharmacokinetics, and IVIVC are emphasized. The future potential of bioavailability enhancement is indicated by emerging trends including stimuli-responsive systems, multifunctional nanocarriers, and AI-assisted formulation design. These trends highlight the importance of rational drug design in creating safe, efficient, and patient-centered treatments.

Keyword: Bioavailability enhancement, Novel drug delivery systems (NDDS), Lipid-based drug delivery, Polymeric and nanocarrier systems, Vesicular drug delivery.