Volume-2 ,Issue-7, July- 2026

Orodispersible tablets (ODTs) are solid dosage forms designed to rapidly disintegrate in the oral cavity without the need for water, offering significant advantages in terms of patient compliance, convenience, and rapid onset of action, particularly for pediatric, geriatric, and dysphagic patients. This review provides a comprehensive overview of ODTs, including formulation considerations, development strategies such as direct compression, freeze-drying, sublimation, and moulding techniques, as well as key technologies like Zydis, Orasolv, Durasolv, Wowtab, and FlashTab systems. The underlying mechanisms of disintegration, including swelling, wicking action, porosity, and the role of saliva, are also discussed in detail. In addition, critical evaluation parameters such as pre-compression properties, mechanical strength, disintegration time, wetting behavior, and dissolution studies are highlighted to ensure product quality and performance. Recent advancements including 3D printing, nanotechnology-based systems, and co-processed excipients are also explored, emphasizing the evolution of ODTs toward more efficient and patient-centric drug delivery systems. Despite their advantages, challenges such as moisture sensitivity, taste masking limitations, and scale-up issues persist, but ongoing innovations continue to expand their therapeutic and commercial potential in modern pharmaceutics.

Keyword: Orodispersible tablets, fast dissolving tablets, superdisintegrants, taste masking, lyophilization, direct compression, 3D printing, nanotechnology, patient compliance, oral drug delivery.