Volume-1 ,Issue-5, December-2025

Improving medication quality, therapeutic efficacy, and patient-centered outcomes all depend on the creation of cutting-edge pharmaceutical formulations. Poor solubility, low bioavailability, stability problems, and systemic adverse effects are among the many drawbacks of conventional dose formulations. Novel formulation techniques, including nanoparticles, lipid-based carriers, polymeric systems, co-crystals, solid dispersions, and 3D-printed customized dosage forms, have been developed to solve these issues. These methods improve patient compliance, facilitate targeted distribution, regulate medication release, and increase solubility. Rational formulation design and optimization have been expedited by recent developments in stimuli-responsive and intelligent delivery methods, computational tools, molecular modeling, and high-throughput screening. Furthermore, preclinical assessments and regulatory frameworks guarantee the quality, safety, and repeatability of these novel systems. This review discusses the difficulties, constraints, and future prospects in converting laboratory innovations into clinically and commercially viable therapies. It also highlights the current trends, technologies, and regulatory considerations in novel formulation development and offers illustrative case studies comparing conventional and advanced products.

Keyword: Novel drug formulations, nanotechnology, lipid-based carriers, 3D printing, controlled release