Abstract
ICARIIN AND CURCUMIN-BASED NOVEL DRUG DELIVERY SYSTEMS FOR OSTEOPOROSIS MANAGEMENT: THERAPEUTIC POTENTIAL, MECHANISMS AND RECENT ADVANCES
Richa Singh, Dr. Sushila kaura
Jayoti Vidyapeeth Women's University, Jaipur
Abstract
Osteoporosis is a chronic skeletal disorder characterized by impaired bone remodeling, reduced bone mineral density and increased fracture susceptibility. This review summarizes the therapeutic potential of icariin and curcumin in osteoporosis, with particular emphasis on their molecular mechanisms and recent advances in novel drug-delivery systems. Recent studies have explored nanoparticles, liposomes, nanoemulsions, hydrogels, biomaterial-based systems and bone-targeted delivery platforms to improve the solubility, stability, bioavailability and therapeutic exposure of these compounds. Emerging evidence also supports investigation of combined icariin-curcumin delivery because of their potentially complementary osteogenic, anti-resorptive, antioxidant and anti-inflammatory activities. Nevertheless, the available evidence remains predominantly preclinical, and substantial challenges remain regarding formulation standardization, pharmacokinetics, dose optimization, long-term safety and clinical validation. Overall, the integration of icariin and curcumin with advanced and bone-targeted drug-delivery technologies represents a promising research direction for improving their therapeutic applicability in osteoporosis and warrants further systematic investigation.
Keyword: Icariin; Curcumin; Osteoporosis; Novel drug delivery systems; Nanocarriers; Bone-targeted delivery; Osteogenesis
Article Information
| Article Type |
Review Article |
| Journal Name |
Global Journal of Pharmaceutical and Scientific Research
|
| ISSN |
3108-0103 |
| Volume |
Volume-2 |
| Issue |
Issue-10, October- 2025 |
| Corresponding Author |
Richa Singh, Dr. Sushila kaura |
| Address |
Jayoti Vidyapeeth Women's University, Jaipur |
| Received |
15 Aug, 2026
|
| Revised |
12 Sep, 2026
|
| Accepted |
25 Sep, 2026
|
| Published |
02 Oct, 2026
|
| Pages |
1560-1587 |
