Volume-1 ,Issue 3, October-2025

Persistent hyperglycemia, insulin resistance, increasing β-cell dysfunction, and problems brought on by oxidative stress are the hallmarks of diabetes mellitus, a chronic metabolic disease. Despite the availability of a number of synthetic antidiabetic medications, their long-term usage is frequently restricted by side effects and insufficient defense against oxidative damage. Derived from traditional medical systems, polyherbal preparations create synergistic hypoglycemic, antioxidant, and anti-inflammatory benefits by combining many therapeutic plants with complimentary processes. In addition to highlighting medicinal plants with proven antidiabetic potential and examining the role of oxidative stress in diabetes, this review also covers the scientific justification, creation, standardization, and assessment of polyherbal formulations. The available clinical evidence, safety, toxicity, herb-drug interactions, regulatory obstacles, and prospects for incorporating polyherbal formulations into conventional diabetic treatment are all rigorously examined.

Keyword: Diabetes mellitus; Polyherbal formulation; Antioxidant activity; Hypoglycemic activity; Oxidative stress; Medicinal plants; Antidiabetic therapy