Abstract
DESIGN, FORMULATION AND EVALUATION OF MEFENAMIC ACID EMULGEL FOR IMPROVED TOPICAL DELIVERY AND ANTI-INFLAMMATORY EFFICACY
Rajesh Kumar Gautam, Dr. Saurabh Parmar
Rishi Ram Naresh College of Pharmacy, Mau, Uttar Pradesh
Abstract
Mefenamic acid is a non-steroidal anti-inflammatory drug with poor aqueous solubility and lipophilic properties, which may limit its suitability for conventional topical delivery. The present study was undertaken to develop and evaluate a Mefenamic acid emulgel for improved topical drug delivery. Ten formulations (F1F10) were prepared using Carbopol 934 as the gelling agent, isopropyl myristate as the oil phase, and Tween 80 and Span 80 as emulsifying agents. The prepared formulations were evaluated for physical appearance, homogeneity, pH, viscosity, spreadability, extrudability, drug content, in-vitro drug release, and stability. All formulations showed satisfactory physical characteristics with acceptable pH and good homogeneity. The drug content of the formulations ranged from 96.5% to 99.7%. Formulation F5 showed satisfactory overall characteristics, with a pH of 6.5, viscosity of 24,890 cP, spreadability of 22.4 g•cm/sec, extrudability of 91.2%, and drug content of 99.6%. F5 exhibited 98.2% cumulative drug release after 12 h and was selected as the optimized formulation based on its overall physicochemical and release profile. Stability studies showed that F5 maintained satisfactory physical appearance, pH, viscosity, and drug content without phase separation during storage. The results indicate that the developed Mefenamic acid emulgel provides satisfactory formulation characteristics and sustained in-vitro drug release, suggesting its potential as a suitable topical delivery system for Mefenamic acid. Further ex-vivo permeation and in-vivo studies are required to confirm its topical performance and anti-inflammatory efficacy. Previous research has also demonstrated the potential of Mefenamic acid emulgels for topical delivery and anti-inflammatory activity.
Keyword: Mefenamic acid; Emulgel; Topical drug delivery; Carbopol 934; Isopropyl myristate; Anti-inflammatory
Article Information
| Article Type |
Research Article |
| Journal Name |
Global Journal of Pharmaceutical and Scientific Research
|
| ISSN |
3108-0103 |
| Volume |
Volume-2 |
| Issue |
Issue-10, October- 2025 |
| Corresponding Author |
Rajesh Kumar Gautam, Dr. Saurabh Parmar |
| Address |
Rishi Ram Naresh College of Pharmacy, Mau, Uttar Pradesh |
| Received |
25 Jul, 2026
|
| Revised |
10 Aug, 2026
|
| Accepted |
15 Sep, 2026
|
| Published |
02 Oct, 2026
|
| Pages |
1515-1528 |
