Volume-1 ,Issue-5, December-2025

Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Calcium dobesilate were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. The prepared tablets of PRE were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. The values of tablets average weight ranging from 642±9 to 659±7 mg. All the tablets passed weight variation test as the % weight variation was within the USP Pharmacopoeia’s limits of ±5 % of the weight. The % drug content of all the formulated tablets were found within the limit. % drug content value of drug was within 98.56±0.14% to 99.85±0.47%. The results within the range indicate uniform of mixing. The maximum drug content was found in formulation F8. Prepared optimized formulation (F8) showed the release of drug form gastroretentive formulation 99.45% after 12 hrs. and marketed formulation showed the release of 98.78% after 2 hrs table 3 & 4. When the regression coefficient values of were compared [14-15], it was observed that ‘R2’ values of zero order was maximum i.e. 0.924 hence indicating drug release from formulations was found to follow zero order kinetics.

Keyword: Calcium dobesilate, floating tablet, gastro retentive, total floating time