Abstract
DESIGN, DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF METOCLOPRAMIDE HCl USING NATURAL SUPERDISINTEGRANTS
Arati Bhardwaj, Harikesh Yadav, Anil kumar Sonkar, Avinash Yadav
Rishi Ramnaresh College of Pharmacy, Mau, Uttar Pradesh, India
Abstract
The present study aimed to formulate and evaluate fast-disintegrating tablets of metoclopramide hydrochloride using Plantago ovata mucilage as a natural superdisintegrant. Six formulations (F1–F6) were prepared by the direct compression technique and evaluated for pre-compression and post-compression parameters, including flow properties, tablet hardness, friability, wetting time, water absorption ratio, drug content, disintegration time, and in-vitro dissolution. Among the developed formulations, F6, containing 18 mg of Plantago ovata mucilage, exhibited the most favourable performance, with a wetting time of 25.12 seconds, water absorption ratio of 92.22%, disintegration time of 21 seconds, and drug content of 99.24%. The formulation achieved 99.12% drug release within 25 minutes. Stability evaluation over six months showed only minor changes in the measured tablet characteristics and dissolution profile. The findings indicate that Plantago ovata mucilage is a promising natural superdisintegrant for developing fast-disintegrating tablets of metoclopramide hydrochloride. Further studies may help establish its suitability for pharmaceutical applications.
Keyword: Fast disintegrating tablets, Plantago ovata, Super disintegrant, Metoclopramide
Article Information
| Article Type |
Research Article |
| Journal Name |
Global Journal of Pharmaceutical and Scientific Research
|
| ISSN |
3108-0103 |
| Volume |
Volume-2 |
| Issue |
Issue-11, November- 2026 |
| Corresponding Author |
Arati Bhardwaj, Harikesh Yadav, Anil kumar Sonkar, Avinash Yadav |
| Address |
Rishi Ramnaresh College of Pharmacy, Mau, Uttar Pradesh, India |
| Received |
15 Aug, 2026
|
| Revised |
21 Sep, 2026
|
| Accepted |
17 Oct, 2026
|
| Published |
02 Nov, 2026
|
| Pages |
1588-1602 |
