Volume-1 ,Issue-1, August-2025

Globally, the usage of herbal supplements and phytomedicines has grown, frequently in conjunction with prescription drugs. Although these items are thought to be harmless and natural, they may result in serious herb-drug interactions that compromise the safety, effectiveness, and general results of treatment. Pharmacokinetic mechanisms, which include alterations in absorption, distribution, metabolism, and excretion, or pharmacodynamic mechanisms, which result in additive, synergistic, or antagonistic effects, might cause such interactions. Dose, duration, patient-specific traits, polypharmacy, and variations in the composition of herbal products are factors that impact interaction risk. Patient education, clinical monitoring, standardized product quality, predictive technologies, and evidence-based standards are all necessary for effective risk management. In an effort to advance safer and more efficient integrative healthcare practices, this study focuses on the mechanisms, clinical consequences, and methods for reducing the hazards related to herb-drug interactions

Keyword: Herb-drug interactions, Phytomedicine, Herbal supplements, Risk assessment, Pharmacokinetics, Pharmacodynamics